SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis.
نویسندگان
چکیده
An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of natural products
دوره 68 8 شماره
صفحات -
تاریخ انتشار 2005